Getting My ceesdekker.net To Work
Getting My ceesdekker.net To Work
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our investigate passions contain:
It was only from the 1990s while, when nanotechnology had Innovative to a stage where solitary molecules could be manipulated, that the primary experimental gadgets commenced to appear.
[Laughs] ‘It absolutely was unquestionably an awesome hazard! At some time, I had been very well informed that it could go Mistaken and that I could turn out to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And by chance it all worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Inside only some months, we had been ready to measure transportation by means of an individual solitary-walled carbon nanotube. Based on lower-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Our analysis ranges with the biophysics of DNA to artificial cells and further than. Be sure to take a look under in the spectrum of our present-day initiatives.
Quite a few similar developments followed, exactly where our group set up distinct transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.
Case in point (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, and also a 3D rendering in the movement from the DNA rod is exhibited.
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one). The current–voltage curves confirmed considerable modulations with gate voltage, even at home temperature, which was in step with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These data also showed which the conductance could possibly be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a home-temperature transistor created from only one carbon nanotube molecule — had been released in Nature in May possibly 1998.
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
2006, very first demonstration of molecular sorting in a very lab on a chip making use of biomotors; discovery of nanobubbles in stable-state nanopores; and very first estimate of electrokinetic Electricity conversion in a nanofluidic channel
Visualization of unstained DNA nanostructures with Innovative in-concentration transmission ceesdekker.net electron microscopy procedures
Good-point out nanopores have tested to generally be a shockingly multipurpose probe for one-molecule Assessment of DNA. I'll describe a number of our latest findings – particularly DNA knots – in addition to our efforts to broaden the capabilities of good-point out nanopores even even further, from the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.